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Re: One more thing.

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Posted by Elizabeth on November 28, 2003 at 15:58:36:

In Reply to: Re: One more thing. posted by Debbie on November 28, 2003 at 14:38:41:

Hi Debbie,

I don't want to cause an argument but current studies state Phenergan as a category C and not B and have seen healthy mothers who actually took this drug and their babies were born with neurological problems, most commonly cerebral palsy.

Here is one article that I got from the Internet and there are many others on the internet as well that state it as a category C. All my medical books also state it as a category C and can cause neurological problems in babies because of its sedating effects.

Promethazine hydrochloride (Phenergan)
Promethazine hydrochloride
Pregnancy Category: C Parenteral: Anergan 50 Phenergan Suppositories: Phenergan Syrup: Phenergan Fortis Phenergan Plain Tablets: Phenergan PMS Promethazine (Rx)

Classification: Antihistamine, phenothiazine-type

See Also: See also Antihistamines and Antiemetics.

Action/Kinetics: Antiemetic effects are likely due to inhibition of the CTZ. Effective in vertigo by its central anticholinergic effect which inhibits the vestibular apparatus and the integrative vomiting center as well as the CTZ. May cause severe drowsiness. Onset, PO, IM, PR: 20 min; IV: 3-5 min. Duration, antihistaminic: 6-12 hr; sedative: 2-8 hr. Slowly eliminated through urine and feces.

Uses: PO and PR for prophylaxis and treatment of motion sickness. Prophylaxis of N&V due to anesthesia or surgery (also postoperatively). Pre- or postoperative sedative, obstetric sedative. Hypersensitivity reactions, including perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioedema, allergic reactions to blood or plasma, dermographism. Adjunct in the treatment of anaphylaxis or anaphylactoid reactions. Adjunct to analgesics for postoperative pain. IV with meperidine or other narcotics in special surgical procedures as bronchoscopy, ophthalmic surgery, or in poor-risk clients.

Contraindications: Lactation. Comatose clients, CNS depression due to drugs, previous phenothiazine idiosyncrasy, acutely ill or dehydrated children (due to greater susceptibility to dystonias). Children up to 2 years of age. SC or intra-arterial use due to tissue necrosis and gangrene.

Special Concerns: Safe use during pregnancy has not been established. Use in children may cause paradoxical hyperexcitability and nightmares. Geriatric clients are more likely to experience confusion, dizziness, hypotension, and sedation.

Additional Side Effects: Leukopenia and agranulocytosis (especially if used with cytotoxic agents).

How Supplied: Injection: 25 mg/mL, 50 mg/mL; Suppository: 12.5 mg, 25 mg, 50 mg; Syrup: 6.25 mg/5 mL, 25 mg/5 mL; Tablet: 12.5 mg, 25 mg, 50 mg

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